ALDH2 Antibody is a Rabbit Polyclonal antibody against ALDH2. Acetaldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. It mediates NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol. Thus, the absence of this enzyme is linked to alcohol intolerance and a reduced risk for alcoholism-related liver disease.

Target	Aldehyde Dehydrogenase, Mitochondrial (ALDH2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 321-480 of human ALDH2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05091 (UniProt, ExPASy)
UniProt Secondary AC	B4DW54, E7EUE5, Q03639, Q6IB13, Q6IV71
UniProt Entry Name	ALDH2_HUMAN
Gene Symbol	ALDH2
GeneID	217
NCBI Accession	NP_000681.2
KEGG	hsa:217
String	9606.ENSP00000261733
Molecular Weight	Calculated MW: 56 kDa Observed MW: 50-56 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	7.93 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Aldehyde Dehydrogenase, Mitochondrial (ALDH2)