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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-Folate Receptor Alpha antibody [BN3.2] (STJ16101741)

  • 產(chǎn)品型號(hào)：STJ16101741-1
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Anti-Folate Receptor Alpha antibody [BN3.2] (STJ16101741)
詳情介紹：
Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Folate Receptor Alpha is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: BN3.2
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Tissue culture supernatant with 15mM Sodium azide
Concentration: >=67 mg/L
Dilution Range: IHC-P 1:100
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: FOLR1
Gene ID: 2348
Uniprot ID: FOLR1_HUMAN
Immunogen: Prokaryotic recombinant protein corresponding to 189 amino acids of the external domain of the folate receptor alpha molecule.
Tissue Specificity Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
Post Translational Modifications The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Protein Name Folate Receptor Alpha
Fr-Alpha
Adult Folate-Binding Protein
Fbp
Folate Receptor 1
Folate Receptor - Adult
Kb Cells Fbp
Ovarian Tumor-Associated Antigen Mov18
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-5694530
Reactome: R-HSA-6807878
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Basolateral Cell Membrane
Gpi-Like-Anchor
Secreted
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Endosome
Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane
Alternative Antibody Names Anti-Folate Receptor Alpha antibody
Anti-Fr-Alpha antibody
Anti-Adult Folate-Binding Protein antibody
Anti-Fbp antibody
Anti-Folate Receptor 1 antibody
Anti-Folate Receptor - Adult antibody
Anti-Kb Cells Fbp antibody
Anti-Ovarian Tumor-Associated Antigen Mov18 antibody
Anti-FOLR1 antibody
Anti-FOLR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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